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I had a very similar situation when I was choosing my first semi-auto handgun. I went in dead set on a Glock 26 for easy carry. I knew I needed to put some rounds down range before I made a decision, so I went out to the range and rented. My first two rentals were the Glock and a Sig P220 (I wanted to get a feel for the difference between composite and alloy). I shot the Glock 26 like crap (most shots falling wide left), and chalked it up to being out of practice. Then I loaded up the P220 and surprised myself with decent clusters at 15 yards. I went back to the Glock and did better, but had no where near the accuracy and precision I had with the larger Sig.

After discussions with the guys in the shop (Red's North in Pflugerville -- great staff) I decided that it might be the sight distance that was causing me trouble. I switched to the Glock 19 and again shot like hell. I cycled through 10 or so other handguns over the course of about a week, including full-size Glocks and compact Sigs. I finally tried adjusting my grip on the Glock by rotating my wrist to the inside -- it made a huge difference. I don't know if that will solve your problems, but it made a ton of difference for me.

Of course, after all those trials, I settled on the P220 and will figure out a way to carry. It felt better and I shot better with it than any other semi that I tried.

Naturally YMMV and happy shooting!