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I vote for the Buckmark over the Ruger for one reason, and one reason only. They are both great pistols with a lot of different variants available on the market. The Ruger has always seemed a little harder to disassemble and reassemble to me (pulling the disassembly lever and getting it back together is a skill that seems slightly different on each Ruger I have tried). The Buckmark comes apart by taking two screws out of the sight mount and goes together easier too.

I am sure you would be satisfied with either and I truly have had several of both.

I would also have to point out that I am impressed by the look and price of the Beretta Neos. I will probably try and buy one of them the next time I look for another 22. I can't say either way on it without having tried it though.