TexasCHLforum.com

I would say it depends on your ammo and your firearm combination.

Several years ago I wondered how many times a round could be chambered without experiencing setback. I took my calipers to the range and proceeded to chamber a round from a full magazine. My combination produced no setback at all and after 50 cycles I quit worrying about it. My carry ammo gets shot up every two months or so and I don't load/unload every other day so it has served me well. Other combinations may not work as well or might even be better. My suggestion is to test yourself and you will know how your combination will perform. Best of luck.