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I carry my Hi-Power cocked and locked. All of my practice drills involve disengaging the safety as I draw, and this has been ingrained in my muscle memory. My gun is ready to fire as soon as I draw it. The key here is actively practicing in the condition that you carry.

My guess would be that the clerk in this situation had rarely (if ever) practiced the use of his firearm, and so was not familiar enough with the operation of his weapon to properly deploy it and thumb the safety off in an emergency situation. Unfortunately, this cost him his life. It is a grim reminder that a BG is not going to wait for you to ready your weapon to defend yourself. Be intimately familiar with quickly deploying your weapon, because your life may depend upon it.