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I'd rather hit them with a fly swatter than miss them with a canon. That said, often the issue isn't missing with the canon, it's not having the canon readily at hand. As others mentioned, what one has at hand is far more capable than what one has at home in the nightstand. It's all compromises. It's up to us individually to decide which compromises we're going to make and which we're going to reject.

The only round I consider inadequate is the non-existent one I'd be willing to be shot with. The problem isn't that a .22 is inadequate, the problem is it takes significantly longer to reach adequacy after hitting the target. The larger the round the quicker adequacy is reached. That said, there's also the wise words "I'd rather hit 'em with a flyswatter than miss 'em with a cannon.".