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I've been carrying since 1987. Always one in the chamber, and these days, cocked-and-locked, since I've been converted into a 1911 nut (which means I went out and shot one, which is all you have to do to become a believer). But I echo those folks who've already answered, become familiar with your weapon, train, and do what is safest for you.

I recently saw a video of a few Israelis who can yank a 1911 without one 'in the pipe' out of their holster, rack the slide, and fire on target faster than some of our best military personnel can draw, flip the safety off, and fire on target, so the key to it all is training, knowledge, and skill.