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I'm not from Houston, so a local may be able to give you better advice. However, when I have to go through there I take 610 to avoid the city center. I tried to take beltway 8 last time when going to Galveston, but the NE part of it was a toll road that you have to buy a special card or tag or something to use. You apparently can't pay cash or just let them mail you a bill like you can with the ones around DFW. I had pretty good luck with 610 the few times I have had to venture through that area. Hope this helps. Good luck.