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For me personally, I wouldn't want to carry SOB, even if it were more comfortable, for the following reason...

I carry a 1911, and I am left handed. Thus, the safety lever that matters to me is protected from inadvertent contact by facing inward, against the holster backing, where it cannot be accidentally switched off. However, the left-side safety lever is exposed. With the pistol on my strong (left) side, protected by my left arm from snagging on anything, the likelyhood that the safety would be accidentally disengaged is fairly minimized. Even so, it has happened to me once (and once only), and I did not discover it until that night when I drew the weapon to put it away for the night. So I have no realistic idea how long I had it that way. Fortunately, the trigger was protected by the holster from being accidentally pulled (not to mention the grip safety), so the gun could not discharge. However, I am afraid that carrying SOB might present more opportunities for the safety lever to get snagged and switched off, making a pistol draw from the SOB position more dangerous to myself or others.

So, I would say that the safety of SOB carry would be largely dependent on what kind of pistol you carry, and whether you are left or right-handed.