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Here's my advice:

1. Take your wife to gun store.
2. Offer her guidance in picking a weapon she likes, is comfortable with, and most importantly, is of a size and sort that she will carry rather than just leaving it at home.
3. Teach her to use said weapon.

Is your wife capable of driving a motor vehicle on a crowded highway at 70+ MPH? If so, then she can clear malfunctions on an autopistol, so don't rule them out.

If she's incapable of doing those things, then consider buying her a sling shot or a pointy stick.