I have an LCP in a pocket hoslter and a Taurus PT145 that I carry in a Supertuck IWB. I prefer to carry the .45 because of the larger caliber. I can carry both or either whether I wear jeans, dress pants and shirt, or shorts.
I wouldn't carry a .22 for self defense. Just my $0.02 worth. And like others have said, it may be worth less than that!