I have a buddy who is a police officer who carries a PXT P14 as his duty weapon. I have not shot it, but he likes it a lot (obviously). It is very large, but manageable. I think you would just have to try handling it to see if it is comfortable to you. I would say that I have average sized hands (wider than average but short stubby fingers) and it felt comfortable to me. My buddies hands are larger and he has really long fingers so the grip is probably very good for him.
If you are in the market for a high capacity .45, take a look at the FNP-45 Tactical. It is not on the FN website, but they don't seem to update too often. There are a few examples on Gunbroker.com. It seems to be very reliable and extremely accurate, but it is not a 1911, so that may be a deal breaker depending on what you are looking for.
