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I have never fired a shot in self defense but I have talked to several SWAT officers from big cities (Houston and Dallas) that have each shot more than a few people in the line of duty. They all shoot 45 ACP. I asked why with all the talk of 9mm being the death ray now and the common answer is that the bad guys just go down faster when hit with a 45. Most were using 1911s but one had a Glock (don't remember the model number but that thing was physically BIG, I have short fingers and it was larger than I could comfortably hold/shoot). Paul Harrell has some videos on this (Charles Cotton mentioned him in a post here in the past and I ended up watching most of his videos, lots of good information). Paul actually has shot someone in self defense (he was using a 10 mm) and talks about that in one of his videos. If I recall correctly, he does not recommend using a 10mm for self defense now and explains that. He likes the 38 super in a 1911 a lot. Hope this helps.