I've got one and used it on my nightstand gun for awhile, but the biggest issue I have with suppressors on pistols for home defense is that they GREATLY increase the likelihood of a malfunction. I've never had a malfunction from the pistol I have setup for my suppressor when it wasn't wearing the can, but there will occasionally be cycling issues when shooting suppressed (my Evo-9 has a booster). It's not a chronic problem, but it has happened enough to make me take the can off for HD duty.
Also, the handgun does become seriously more cumbersome with all that weight up front. It's probably less of an issue when playing high-speed at the range, but waking up groggy in the middle of the night and potentially firing from a weird and less than ideal shooting position - no thanks. If you ever got into a confrontation with someone in your home - if they caught you by surprise or whatever - the can will give them much more leverage on working to disarm you, and any outside force disturbing the can will almost certainly induce a malfunction.
It's cool and everything, but I don't think cans belong on home defense handguns. Short-barrel or bullpup rifles, on the other hand...