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I like CA Technologies (formally Computer Associates). They cater to the corporate client, however, they have a Home Office offering. Most of their virus protection products include license keys for three computers. It has served us well and we have not had issue in the five plus years we have used it. Install it, configure the options (updates, complete scans, etc....) and forget it.

It also plays very well with Mozilla Firefox and Open Office. This is important as I am not much of a Microsoft Application fan.