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Lot of things to factor in. How experienced are you with handguns? How large are your hands? How strong are your hands?

The MUCH better half is a munchkin, well under 5'. She has tiny hands and almost no hand strength. What fit HER the best was a SIG P238. It fits her tiny hands well, and even with her lack of hand strength she can fully operate it (load, cycle the slide, etc.). Many autos she couldn't even work the slide. She loves that little mousegun. But she also has a revolver that she had when we met and she's a real good shot with that one. It's her nightstand gun given that it's a bit large to CC. The little SIG is easy to hide. But those are what works for her. Long before I met her I was dating another munchkin (what is it with me and short women?). Found the gun she was most comfortable with was an Officers 1911. She had no problems working that one. There's no way the MUCH better half can cycle the slide on any of my 1911s. I'd like to get her to try a 9mm version, but that's another story.

Point here being, two ladies roughly the same size chose two different handguns. Best thing is to handle a lot of them. Some you can strike right away as they won't fit your hands. Some you may have difficulty operating. But once you weed out the non-starters, then you can go shoot a few to find the one you're most comfortable with.