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I have a friend who bought the Taurus PT145, but he is now considering selling it. I think that is more about that model and not Taurus in general though. I don't have any experience with Taurus either. Never really heard much good or bad.

I've had a Glock 22 for years and never had any issues with it. I know a guy who just got a Glock 21 in 45 and it shot reliably and surprisingly accurate. IMO, it is a very good choice. The main issue is to practice keeping your finger off the trigger and make sure everyone in your family who might come in contact with it understands that and how to properly unload it (remove mag, check the chamber). My only problem with Glocks is I don't like their compact models so I was only ever interested in their full size pistols.

IMO, most of the safety issues with Glocks are issues that affect ANY semi-auto pistol. In reality, you really should not trust your life to a mechanical safety.

The only other brand I could mention is CZ. The CZ 75 models are good pistols if you are interested in 9mm or 40. My CZ 75 P01 and P06 pistols in 9 and 40 are rock solid and pretty compact.