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My wife purchased one for plinking and target practice as she "caught the bug" just recently, and with her very small hands the P22's grip fit like a charm. They include a couple grip back straps as well, so you can swap those out if desired. We did have to send it back under warranty the very week she bought it though (after the first ~120 rounds, the hammer spring broke). We got it back from Walther (S&W) a couple weeks later and it's worked great ever since, though we've only put about another 350-400 rounds through it after the repair.

I've heard on other forums that the P22 is particular about its diet, but we've found Remington Golden Bullet hollow points in bulk cartons not to be a problem. I've also heard that a lot of the feeding problems in the past had to do with the magazine, and that a newer style magazine (which has an "A" in its part number) is what you need to make sure you get, or pick up, if you buy an older P22 that has the old-style magazine. Out of the two magazines that came with it, we've perhaps have only had three FTF or jams so far (and two of those were before the hammer spring repair), but it's only now getting broken in.

As KennyLee mentioned, I've also read on some forums that the barrel nut needs to be checked often for loosening, but we haven't experienced that yet. It might cause more problems for those that purchase the P22 with both barrel lengths (swapping the barrels), but since we only have the shorter barrel if loosening occurs I'll probably just use a tiny bit of Loc-Tite or something to cure it.

Overall we've had a blast with that little P22. It's quite accurate at 15 yds. with the stock sights (3 front sights and a flat plug come with it... we swapped out the #1 front sight with the #2 front sight and left the rear windage-adjustable sight unchanged), and makes for a dandy little plinker.