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It's a tough choice, but much depends on tactical advantage , or disadvantage, and timing. Are you steady enough to be sure you're going to get your gun out and shoot the perpetrators before they can kill the clerk and\/or shoot you?

Remember, people don't necessarily die immediately when shot. They could still get off a round or two and kill the clerk you are trying to protect. OTOH if you don't engage, they may just leave with the money doing no harm to anyone.

Can you live with yourself if the clerk is killed because you opened fire?

It's a tough choice requiring good judgement and steady nerves, as well as deadly accuracy. Ever been in a gunfight before? Think before you engage.